Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design

Application of Bioisosteres in Drug Design

Carbohydrate Derivatives and Glycomimetic Compounds in Established and Investigational Therapies of Type 2 Diabetes Mellitus

Diabetes mellitus is characterized by chronically elevated serum glucose levels resulting in damage of several tissues (e. g. retina, kidney, nerves) due to higher protein glycation, retardation of wound healing, impaired insulin secretion, enhanced insulin resistance, cell apoptosis, and increased oxidative stress. Type 2 diabetes (T2DM), representing 90-95 % of all diabetic cases, is a multif...

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.

Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

Carbohydrate blood groups

Blood group antigens of the H, ABO, Lewis, and historical “P” blood groups are defined by small carbohydrate epitopes expressed as posttranslational modifications on glycoproteins, mucins, and glycolipids. Their synthesis is complex and dependent on several distinct glycosyltransferases and interrelated biosynthetic pathways. In many cases, carbohydrate antigens share features of more than one ...

investigating the integration of translation technologies into translation programs in iranian universities: basis for a syllabus design in translation technology

today, information technology and computers are indispensable tools of any profession and translation technologies have become an indispensable part of translator’s workstation. with the increasing demands for high productivity and speed as well as consistency and with the rise of new demands for translation and localization, it is necessary for translators to be familiar with market demands an...